Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: 2-8°C

IATA: Hazard Class: 6.1; UN Number: UN1544; Packing Group: III; Shipping Name: Alkaloids, solid, n.o.s ((S)-(+)-Camptothecin)

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(S)-(+)-Camptothecin binds irreversibly to the DNA-topoisomerase I complex, inhibiting the reassociation of DNA after cleavage by topoisomerase I and traps the enzyme in a covalent linkage with DNA. The enzyme complex is ubiquinated and destroyed by the 26S proteasome, thus depleting cellular topoisomerase I. Blocks the cell cycle in S-phase at low does and induces apoptosis in a large number of normal and tumor cell lines by cell cycle-dependent and cell cycle-independent processes.