Product: | Dolasetron Mesylate | ||||||||
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Catalog Number: | 17450 | ||||||||
Synonyms: |
Dolasetron mesylate hydrate; Dolasetron methanesulfonate hydrate |
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Pricing: |
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Formula: | C19H20N2O3 • CH4O3S • xH2O | ||||||||
Chemical Purity: | >98% | ||||||||
Molecular Weight: | 420.48 | ||||||||
Structure: | |||||||||
Appearance: | White powder | ||||||||
Category: | Anti-cancer compounds | ||||||||
Stability: | Stable under recommended storage conditions | ||||||||
Storage: |
Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: 2-8°C |
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Transportation: |
Non-hazardous for transport |
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Literature References: |
Vergne-Salle, P., et al., A randomised, double-blind, placebo-controlled trial of dolasetron, a 5-hydroxytryptamine 3 receptor antagonist, in patients with fibromyalgia Eur. J. Pain, (2010); Mandanas, R.A., et al., A randomized, multicenter, open-label comparison of the antiemetic efficacy of dolasetron versus ondansetron for the prevention of nausea and vomiting during high-dose myeloablative chemotherapy Support. Cancer Ther. 2, 114-121, (2005); Kuryshev, Y.A., et al., Interactions of the 5-hydroxytryptamine 3 antagonist class of antiemetic drugs with human cardiac ion channels J. Pharmacol. Exp. Ther. 295, 614-620, (2000) |
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MSDS: | |||||||||
Description: |
Dolasetron mesylate hydrate is a highly specific and selective serotonin 5-HT3 receptor antagonist, not shown to have activity at other known serotonin receptors and with low affinity for dopamine receptors. |