Product: Eflornithine HCl hydrate
Catalog Number: 17462
CAS Number: 70052-12-9 (free base)
Synonyms: DL-α-Difluoromethylornithine hydrochloride hydrate; DMFO hydrochloride hydrate;
2-(Difluoromethyl)ornithine hydrochloride hydrate
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Formula: C6H12F2N2O2 . xHCl . yH2O
Chemical Purity: >97%
Molecular Weight: 182.17
Structure: Eflornithine HCl hydrate
Appearance: White solid
Category: Anti-cancer compounds
Stability: Stable under recommended storage conditions
Storage:

Keep container tightly closed in a dry and well-ventilated place.
Transportation:

Non-hazardous for transport
Literature References:

Sharma, S., et al., , A quantitative angiogenesis model for efficacy testing of chemopreventive agents. Anticancer Res. 21, 3829-3837, (2001); Takahashi, Y., et al., α-Difluoromethylornithine induces apoptosis as well as anti-angiogenesis in the inhibition of tumor growth and metastasis in a human gastric cancer model. Int. J. Cancer 85, 243-247, (2000); Jasnis, M.A., et al., Polyamines prevent DFMO-mediated inhibition of angiogenesis. Cancer Lett. 79, 39-43, (1994); Takigawa, M., et al., Tumor angiogenesis and polyamines: α-difluoromethylornithine, an irreversible inhibitor of ornithine decarboxylase, inhibits B16 melanoma-induced angiogenesis in ovo and the proliferation of vascular endothelial cells in vitro. Cancer Res. 50, 4131-4138, (1990); Merck 14,3522
MSDS:
Description:

Difluoromethylornithine (Eflornithine) inhibits polyamine biosynthesis by the selective, irreversible inhibition of ornithine decarboxylase (ODC). A chemoprotective agent that blocks angiogenesis.