Kohyama, N., et al. 1997. Biosci. Biotechnol. Biochem. 61: 347-350; 2. Manna, C., et al. 1997. J. Nutr. 127: 286-292; Palmerini, C.A., et al. 2005. J. Nutr. Biochem. 16: 109-113; Guichard, C., et al. 2006. Carcinogenesis. 27: 1812-1827.

3,4-Dihydroxyphenyl Ethanol is a phenolic compound present in olive oil, described to inhibit 5-lipoxygenase (5-LO) and 12-lipoxygenase activity (12-LO). 3,4-Dihydroxyphenyl Ethanol is demonstrated to inhibit 5-LO (IC₅₀ = 13 μM) in rat polymorphonuclear leukocytes and 12-LO (IC₅₀ = 4.2 μM) in rat platelets. Oxidative damage induced by H₂O₂ or a xanthine/xanthine oxidase system on human Caco-2 cells was strongly suppressed by exposure to 3,4-Dihydroxyphenyl Ethanol, indicating reactive oxygen species scavenging activity of the compound. 3,4-Dihydroxyphenyl Ethanol is demonstrated to increase cytosolic Ca²⁺ levels in human lymphomonocytes. 3,4-Dihydroxyphenyl Ethanol is also described to induce growth arrest and apoptosis in human colon carcinoma HT-29 cells through activation of the serine/threonine protein phosphatase 2A