Inquire About a Product| Product: | Eflornithine HCl | ||||||||
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| Catalog Number: | 5431 | ||||||||
| CAS Number: | 70052-12-9 | ||||||||
| Synonyms: |
DMFO Hydrochloride; 2-(Difluoromethyl)-DL-ornithine monohydrochloride; H-DL-(a-difluoromethyl)Orn-OH |
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| Pricing: |
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| Formula: | C6H12F2N2O2 • HCl | ||||||||
| Molecular Weight: | 218.63 | ||||||||
| Structure: |
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| Appearance: | White solid | ||||||||
| Category: | Unlabeled Reference Standards | ||||||||
| Stability: | Stable under recommended storage conditions | ||||||||
| Storage: |
Keep container tightly closed in a dry and well-ventilated place |
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| Transportation: |
Non-hazardous for transport |
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| Literature References: |
Meizel, S. and Turner, K.O. 1993. Mol. Reprod. Dev. 34: 457-465; Takahashi, Y., et al. 2000. Int. J. Cancer. 85: 243-247; Raul, F., 2007. Biochem. Soc. Trans. 35: 353-355. |
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| MSDS: | |||||||||
| Description: |
DFMO Hydrochloride is a specific irreversible inhibitor of ornithine decarboxylase, which shows antiapoptotic, antiparasitic, and antiangiogenic activity. DMFO Hydrochloride also suppresses polyamine biosynthesis. Studies on mice indicate that DMFO Hydrochloride suppresses the liver metastasis in the KKLS gastric cell line. DFMO Hydrochloride is also used as an inhibitor of putrescine synthesis catalyzed by ornithine decarboxylase. In addition, DFMO Hydrochloride suppresses the acrosome reaction in human sperm, which can be reversed by putrescine |