Inquire About a Product| Product: | 1-(5-Isoquinolinesulfonyl)-1H-hexahydro-1,4-diazepine DiHCl | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Catalog Number: | 11238 | ||||||||
| CAS Number: | 203911-27-7 | ||||||||
| Synonyms: |
HA1077 Dihydrochloride; Fasudildihydrochloride; 1-(5-Isoquinolinylsulfonyl)homopiperazinedihydrochloride |
||||||||
| Pricing: |
|
||||||||
| Formula: | C14H17N3O2S • 2HCl | ||||||||
| Molecular Weight: | 364.29 | ||||||||
| Structure: |
|
||||||||
| Appearance: | Off-White Solid | ||||||||
| Category: | Protein Kinase Inhibitors and Activators | ||||||||
| Stability: | Stable under recommended storage conditions. | ||||||||
| Storage: |
Keep container tightly closed in a dry and well-ventilated place |
||||||||
| Transportation: |
Non-hazardous for transport |
||||||||
| Literature References: |
Shirotani, et al., A new type of vasodilator HA 1077 an isoquinoline derivative inhibits proliferation of bovine vascular smooth muscle cells in culture. J. Pharmacol. Exp. Ther. 259, 738, (1991); Seto, et al., Effects of HA 1077 a protein kinase inhibitor on myosin phosphorylation and tension in smooth muscle. Eur. J. Pharmacol. 195, 267, (1991); Asano, et al., Vasodilator actions of HA 1077 in vitro and in vivo putatively mediated by the inhibition of protein kinase. Br. J. Pharmacol. 98, 1091, (1989); Merck 14,3942 |
||||||||
| MSDS: | |||||||||
| Description: |
Novel vasodilator agent which inhibits vascular smooth muscle contraction by acting as an intracellular Ca2+ antagonist. |