Inquire About a Product| Product: | seco Rapamycin sodium salt | ||||
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| Catalog Number: | 13354 | ||||
| CAS Number: | 148554-65-8 | ||||
| Pricing: |
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| Formula: | C51H78NO13Na | ||||
| Chemical Purity: | 87.6% | ||||
| Molecular Weight: | 936.15 | ||||
| Structure: |
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| Appearance: | Yellow solid | ||||
| Category: | Metabolites and Impurities | ||||
| Stability: | Stable under recommended storage conditions. | ||||
| Storage: |
Keep tightly closed. Store in a cool dry place. |
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| Transportation: |
Non-hazardous for transport |
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| Literature References: |
Paine, M.F., et al. 2002. J. Pharmacol. Exp. Ther. 301: 174-186. PMID: 11907172; Paine, M.F., et al. 2004. Ther Drug Monit. 26: 463-467. PMID: 15385826 |
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| MSDS: | |||||
| Applications: |
seco Rapamycin Sodium Salt is a decomposition product of Rapamycin which can function as an antifungal agent. seco Rapamycin Sodium Salt is the open ring conformation of Rapamycin. Studies suggest that seco Rapamycin Sodium Salt is impermeable to the apical membrane in Caco-2 cells. It has also been observed that seco Rapamycin Sodium Salt can be secreted across the apical membrane, which can be inhibited by the P-gp inhibitor, LY335979. In contrast, Rapamycin is cell permeable and can functions as a CYP3A4/P-gp substrate |