Keep container tightly closed in a dry and well-ventilated place.

Non-hazardous for transport

Gilman, A.G. and Goodman, L.S., ed. Goodman and Gilman’s The Pharmacological Basis of Therapeutics 9th ed.,, (1996) 9, 1229, 1274-1275; Sun, L., et al., In Vivo Alternative Assessment Of The Chemicals That Interfere With Anterior Pituitary POMC Expression And Interrenal Steroidogenesis In POMC: EGFP Transgenic Zebrafish. Toxicol. Appl. Pharmacol. 248, 217-25, (2010); Merck 14,440; Beil. 22,IV,6596; Aldrich MSDS 1, 85:A / Corp MSDS 1 (1), 177:A / FT-IR 2 (2), 3072:B / FT-IR 1 (2), 404:A / FT-NMR 1 (2), 1456:C / RegBook 1 (2), 2079:F / Sigma FT-IR 1 (1), 616:C / Structure Index 1, 329:B:2

DL-Aminoglutethimide is a derivative of the sedative glutethimide. Originally introduced as an anticonvulsant, it was found to cause adrenal insufficiency. Blocks adrenal steroidogenesis by inhibiting the enzymatic conversion of cholesterol to pregnenolone. It also blocks the peripheral conversion (aromatization) of androgenic precursors to estrogens. TheD-isomer is 30 times more potent at inhibiting aromatase activity, whereas theL-isomer is more potent at inhibiting cholesterol side-chain cleavage (steroidogenesis).