Product: | Cladribine | ||||
---|---|---|---|---|---|
Catalog Number: | 17421 | ||||
CAS Number: | 4291-63-8 | ||||
Synonyms: |
2-Chloro-2’-deoxyadenosine; CdA |
||||
Pricing: |
|
||||
Formula: | C10H12ClN5O3 | ||||
Chemical Purity: | 97% | ||||
Molecular Weight: | 285.69 | ||||
Structure: | |||||
Appearance: | Solid | ||||
Category: | Anti-cancer compounds | ||||
Stability: | Stable under recommended storage conditions | ||||
Storage: |
Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: 2-8°C. |
||||
Transportation: |
Non-hazardous for transport |
||||
Literature References: |
Bryson, H.M. and Sorkin, E.M. Drugs 46, 872, (1993); Carson, D.A., et al. Proc. Natl. Acad. Sci. U. S. A. 81, 2232, (1984); Merck 14,2337 |
||||
MSDS: | |||||
Description: |
Cladribiane, like fludarabine, is a prodrug that is must be phosphorylated intracellularly to the monophosphate by the nuclear/cytosol enzyme deoxycytidine kinase (dCK) and possibly by the mitochondrial enzyme deoxyguanosine kinase (dGK). Clinically used for treatment of hairy cell leukemia, chronic lymphocytic leukemia and other indolent leukemias |