Inquire About a Product| Product: | Lomustine | ||||
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| Catalog Number: | 17546 | ||||
| CAS Number: | 13010-47-4 | ||||
| Synonyms: | 1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea | ||||
| Pricing: |
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| Formula: | C9H16ClN3O2 | ||||
| Chemical Purity: | >98% | ||||
| Molecular Weight: | 233.70 | ||||
| Structure: |
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| Appearance: | Light yellow powder | ||||
| Category: | Anti-cancer compounds | ||||
| Stability: | Stable under recommended storage conditions | ||||
| Storage: |
Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: -20°C. Light sensitive. |
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| Transportation: |
IATA: Hazard Class: 6.1; UN Number: UN2811; Packing Group: III; Shipping Name: Toxic solid, organic, n.o.s. (Lomustine) |
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| Literature References: |
Hartley, J.A., et al., DNA sequence selectivity of guanine-N7 alkylation by three antitumor chloroethylating agents. Cancer Res. 46, 1943-7, (1986); Brent, T.P., Inactivation of purified human O6-alkylguanine-DNA alkyltransferase by alkylating agents or alkylated DNA. Cancer Res. 46, 2320-3, (1986); Dean, S.W., et al., A comparative analysis of drug-induced DNA effects in a nitrogen mustard resistant cell line expressing sensitivity to nitrosoureas. Biochem. Pharmacol. 35, 1171-6, (1986); Aquilina, G., et al., Mismatch repair and p53 independently affect sensitivity to N-(2-chloroethyl)-N'-cyclohexyl-N-nitrosourea. Clin. Cancer Res. 6, 671-80, (2000); Merck 14,5564 |
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| MSDS: | |||||
| Description: |
Antineoplastic agent with cellular DNA effects.1,2,3 Lomustine induces p53 expression in A2870 cells.4 |