Inquire About a Product| Product: | Phorbol 12-myristate 13-acetate | ||||||||
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| Catalog Number: | 74793 | ||||||||
| CAS Number: | 16561-29-8 | ||||||||
| Synonyms: |
TPA; 12-O-Tetradecanoylphorbol 13-acetate, PMA, TPA |
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| Pricing: |
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| Formula: | C36H56O8 | ||||||||
| Chemical Purity: | >99.5% | ||||||||
| Molecular Weight: | 616.8 | ||||||||
| Structure: |
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| Appearance: | Powder | ||||||||
| Category: | Anti-cancer compounds | ||||||||
| Storage: | 2 years at -20°C | ||||||||
| Solubility: | Soluble in Ethanol and DMSO | ||||||||
| Literature References: |
1. Huang (2014). "Megakaryocytic Differentiation of K562 Cells Induced by PMA Reduced the Activity of Respiratory Chain Complex IV". PLoS ONE. 9 (5): e96246. doi:10.1371/journal.pone.0096246. 2. The AGT cytogenetics laboratory manual. 3rd ed. Barch, Margaret J., Knutsen, Turid., Spurbeck, Jack L., eds. 1997. Lippincott-Raven. 3. "Flow Cytometry Intracellular Staining Guide". eBioscience, Inc. Retrieved 2011-09-25. |
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| MSDS: | |||||||||
| Description: | The TPA is used to stimulate the division of B-cells during cytogenetic diagnosis of B-cell cancers such as chronic lymphocytic leukemia. TPA is also used as standard in LC/MS analysis. | ||||||||
| Applications: | As a phorbol ester, it works as a tumor promoter and is involved in gene transcription, cell growth, differentiation, programmed cell death, immune pathway and receptor desensitization via protein kinase C (PKC) signaling pathways. Phorbol 12-myristate 13-acetate is also a model agent to study growth factors-, hormones-, and cytokines-mediated regulation of cellular growth and differentiation. | ||||||||
| Biochemical Behavior: | Biochem/physiol Actions Potent tumor promoter; activates protein kinase C in vivo and in vitro. |