Inquire About a Product| Product: | Midostaurin | ||||
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| Catalog Number: | 17568 | ||||
| CAS Number: | 120685-11-2 | ||||
| Synonyms: |
CGP 41251; PKC-412; N-benzoylstaurosporine; N-[(9S,10R,11R,13R)-2,3,10,11,12,13-Hexahydro-10-methoxy-9-methyl-1-oxo-9,13-epoxy,1H,9H-diindolo[1,2,3-gh:3’,2’,1’-lm]pyrrolo[3,4-j][1,7]benzodiazonin-11-yl]-N-methylbenzamide |
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| Pricing: |
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| Formula: | C35H30N4O4 xH2O | ||||
| Molecular Weight: | 570.64 | ||||
| Appearance: | Off-white solid | ||||
| Category: | Anti-cancer compounds | ||||
| Stability: | Stable under recommended storage conditions | ||||
| Storage: |
Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: -20°C. |
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| Transportation: |
Non-hazardous for transport |
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| Literature References: |
Wang, Y. et al., Dose- and time-dependent pharmacokinetics of midostaurin in patients with diabetes mellitus J. Clin. Pharmacol. 48, 763-775, (2008); Barry, E.V. et al., Uniform sensitivity of FLT3 activation loop mutants to the tyrosine kinase inhibitor midostaurin Blood 110, 4476-4479, (2007); Li, H. et al., Midostaurin upregulates eNOS gene expression and preserves eNOS function in the microcirculation of the mouse Nitric Oxide 12, 231-236, (2008) |
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| MSDS: | |||||
| Description: |
Midostaurin is an inhibitor of tyrosine kinase, protein kinase C, and VEGF. Midostaurin inhibits cell growth and phosphorylation of FLT3, STAT5, and ERK. It is a potent inhibitor of a spectrum of FLT3 activation loop mutations. |