Store at 4°C

Migliorati, G., et al. 1994. Arzneimittelforschung. 44: 1421-1424; Gourgiotis, D., et al. 2004. J Asthma. 41: 285-287; Riboldi, P., et al. 2009. Int J Immunopathol Pharmacol. 22: 255-262; Giagulli, C., et al. 2009. Int. Immunopharmacol. 9: 1366-1373.

Pidotimod is a synthetic dipeptide with immunological modulatory activity on both the adaptive and innate immune responses. This compound has been shown to induce dendritic cell maturation and up-regulate the expression of HLA-DR and co-stimulatory molecules CD83 and CD86, which are integral to communication with adaptive immunity cells. Pidotimod has also been shown to stimulate dendritic cells to release pro-inflammatory molecules such as MCP-1 and TNF-α cytokines, and to inhibit thymocyte apoptosis caused by a variety of apoptosis inducing molecules