Product: | Acenocoumarol | ||||||||
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Catalog Number: | 4791 | ||||||||
CAS Number: | 152-72-7 | ||||||||
Synonyms: | 3-(a-acetonyl-p-nitrobenzyl)-4-hydroxy-coumarin; (±)-Acenocoumarin; (±)-Acenocoumarol; G 23350 | ||||||||
Pricing: |
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Formula: | C19H15NO6 | ||||||||
Chemical Purity: | >98% | ||||||||
Molecular Weight: | 353.33 | ||||||||
Structure: | |||||||||
Appearance: | Solid | ||||||||
Category: | Unlabeled Reference Standards | ||||||||
Stability: | Stable under recommended storage conditions | ||||||||
Storage: |
Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: -20°C |
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Transportation: |
Non-hazardous for transport |
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Literature References: |
Ufer, M., Comparative pharmacokinetics of vitamin K antagonists warfarin, phenprocoumon and acenocoumarol. Clin. Pharmacokinet. 44, 1227-1246, (2005); Thijssen, H.H., Flinois, J., Beaune, P.H., Cytochrome P4502C9 is the principal catalyst of racemic acenocoumarol hydroxylation reactions in human liver microsomes. Drug Metab. Dispos. 28, 1284-1290, (2000); Beinema M, Brouwers JR, Schalekamp T, Wilffert B, Pharmacogenetic differences between warfarin, acenocoumarol and phenprocoumon. Thromb. Haemost. 100, 1052-1057, (2008) |
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MSDS: | |||||||||
Description: |
Acenocoumarol is a warfarin analog, an anticoagulant that inhibits Vitamin K epoxide reductase. This results in depletion of the reduced form of vitamin K (vitamin KH2), limiting the gamma-carboxylation and subsequent activation of the vitamin K-dependent coagulation factors II, VII, IX, and X and anticoagulant proteins C and S, resulting in decreased prothrombin levels and the amount of thrombin generated. Warfarin analog; anticoagulant; inhibitor of Vit K epoxide reductase |