Inquire About a Product| Product: | Acenocoumarol | ||||||||
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| Catalog Number: | 4791 | ||||||||
| CAS Number: | 152-72-7 | ||||||||
| Synonyms: | 3-(a-acetonyl-p-nitrobenzyl)-4-hydroxy-coumarin; (±)-Acenocoumarin; (±)-Acenocoumarol; G 23350 | ||||||||
| Pricing: |
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| Formula: | C19H15NO6 | ||||||||
| Chemical Purity: | >98% | ||||||||
| Molecular Weight: | 353.33 | ||||||||
| Structure: |
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| Appearance: | Solid | ||||||||
| Category: | Unlabeled Reference Standards | ||||||||
| Stability: | Stable under recommended storage conditions | ||||||||
| Storage: |
Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: -20°C |
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| Transportation: |
Non-hazardous for transport |
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| Literature References: |
Ufer, M., Comparative pharmacokinetics of vitamin K antagonists warfarin, phenprocoumon and acenocoumarol. Clin. Pharmacokinet. 44, 1227-1246, (2005); Thijssen, H.H., Flinois, J., Beaune, P.H., Cytochrome P4502C9 is the principal catalyst of racemic acenocoumarol hydroxylation reactions in human liver microsomes. Drug Metab. Dispos. 28, 1284-1290, (2000); Beinema M, Brouwers JR, Schalekamp T, Wilffert B, Pharmacogenetic differences between warfarin, acenocoumarol and phenprocoumon. Thromb. Haemost. 100, 1052-1057, (2008) |
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| MSDS: | |||||||||
| Description: |
Acenocoumarol is a warfarin analog, an anticoagulant that inhibits Vitamin K epoxide reductase. This results in depletion of the reduced form of vitamin K (vitamin KH2), limiting the gamma-carboxylation and subsequent activation of the vitamin K-dependent coagulation factors II, VII, IX, and X and anticoagulant proteins C and S, resulting in decreased prothrombin levels and the amount of thrombin generated. Warfarin analog; anticoagulant; inhibitor of Vit K epoxide reductase |