Product: Phorbol 12-myristate 13-acetate
Catalog Number: 74793
CAS Number: 16561-29-8
Synonyms: TPA;
12-O-Tetradecanoylphorbol 13-acetate, PMA, TPA
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Formula: C36H56O8
Chemical Purity: >99.5%
Molecular Weight: 616.8
Structure: Phorbol 12-myristate 13-acetate
Appearance: Powder
Category: Anti-cancer compounds
Storage: 2 years at -20°C
Solubility: Soluble in Ethanol and DMSO
Literature References:

1. Huang (2014). "Megakaryocytic Differentiation of K562 Cells Induced by PMA Reduced the Activity of Respiratory Chain Complex IV". PLoS ONE. 9 (5): e96246. doi:10.1371/journal.pone.0096246.

2. The AGT cytogenetics laboratory manual. 3rd ed. Barch, Margaret J., Knutsen, Turid., Spurbeck, Jack L., eds. 1997. Lippincott-Raven.

3. "Flow Cytometry Intracellular Staining Guide". eBioscience, Inc. Retrieved 2011-09-25.

Description: The TPA is used to stimulate the division of B-cells during cytogenetic diagnosis of B-cell cancers such as chronic lymphocytic leukemia. TPA is also used as standard in LC/MS analysis.
Applications: As a phorbol ester, it works as a tumor promoter and is involved in gene transcription, cell growth, differentiation, programmed cell death, immune pathway and receptor desensitization via protein kinase C (PKC) signaling pathways. Phorbol 12-myristate 13-acetate is also a model agent to study growth factors-, hormones-, and cytokines-mediated regulation of cellular growth and differentiation.
Biochemical Behavior: Biochem/physiol Actions Potent tumor promoter; activates protein kinase C in vivo and in vitro.