Product: 24-Hydroxycholesterol-25,26,26,26,27,27,27-d7
Catalog Number: D730
CAS Number: 144154-78-9
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Enrichment: 98%D
Molecular Weight: 409.70
Structure: 24-Hydroxycholesterol-25,26,26,26,27,27,27-d<sub>7</sub>
Category: Cholesterol
Literature References:

Bjorkhem, I., Lutjohann, D., Breuer, O., Sakinis, A., Wennmalm, A., Importance of a Novel Oxidative Mechanism for Elimination of Brain Cholesterol Turnover of Cholesterol and 24(S)-Hydroxycholesterol in Rat Brain as Measured with 18O2Techniques in vivo and in vitro. The Journal of Biological Chemistry, 1997, Nov., 272:30178-30184.; Kolsch, H., Lutjohann, D., Tulke, A., Bjorkhem, A., Rao, M.L., The neurotoxic effect of 24-hydroxycholesterol on SH-SY5Y human neuroblastoma cells. Brain Research, 1999, Feb., 818(1):171-175.

Description: A labeled derivative of cholesterol. Synthesized exclusively in the brain. Possesses the ability to cross the blood-brain barrier. Maintains brain cholesterol homeostasis. Precursor to bile acids. Correlation between increased levels of the compound and the occurrence of active demyelinating diseases such as Alzheimer’s disease.