Product: (RS)-S-Adenosyl-L-methionine-d3 tetra(p-toluenesulfonate) salt
Catalog Number: D998
Unlabeled CAS Number: 17176-17-9
Synonyms: Adenosine-5’-methionine-d3 p-Toluenesulfonate;
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Formula: C15H19D3N6O5S • 4 C7H8O3S
Molecular Weight: 1089.24
Structure: (RS)-S-Adenosyl-L-methionine-d3 tetra(p-toluenesulfonate) salt
Appearance: White solid
Category: Nucleic Acids - 13C, 15N Alphabetical Listing
Stability: Stable under recommended storage conditions.

KEEP FROZEN. Adequate ventilation. Protect from moisture


Non-hazardous for transport

Literature References:

Bressa, GM, S-adenosyl-l-methionine (SAMe) as antidepressant: meta-analysis of clinical studies. Acta Neurol Scand Suppl. 1994, 154: 7–14.; Cantoni, GL, The Nature of the Active Methyl Donor Formed Enzymatically from L-Methionine and Adenosinetriphosphate. J Am Chem Soc, 1952, 74 (11): 2942–3.; Kagan, BL; Sultzer, DL; Rosenlicht, N; Gerner, RH, Oral S-adenosylmethionine in depression: a randomized, double-blind, placebo-controlled trial. Am J Psychiatry, 1990, May 147 (5): 591–5.; Papakostas, GI, Role of S-adenosyl-L-methionine in the treatment of depression: a review of the evidence. Am J Clin Nutr., 2002, Nov., 76(5): 1158S–61S.;  Rosenbaum, JF; Fava, M; Falk, WE; Pollack, MH; Cohen, LS; Cohen, BM; Zubenko, GS, The antidepressant potential of oral S-adenosyl-l-methionine. Acta Psychiatrica Scandinavica, 1990, May, 81 (5): 432–6.

Applications: Labeled compound. Used in the US as a nutritional supplement. Studies have shown if taken on a regular basis, the compound may help fight depression, liver disease, and the pain of osteoarthritis. Transmethylation, transsulfuration and aminopropylation are the metabolic pathways that require S-adenosyl methionine.