Product: | Homoharringtonine | |
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Catalog Number: | 17514 | |
CAS Number: | 26833-87-4 | |
Synonyms: | Omacetaxine | |
Pricing: |
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Formula: | C29H39NO9 | |
Molecular Weight: | 545.62 | |
Structure: | ||
Appearance: | Solid | |
Category: | Anti-cancer compounds | |
Stability: | Stable under recommended storage conditions | |
Storage: |
Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: 2-8°C |
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Transportation: |
IATA: Hazard Class: 6.1; UN Number: UN1544; Packing Group: II; Shipping Name: Alkaloids, solid, n.o.s. (Homoharringtonine) |
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Literature References: |
Zhou, D.C., et al., Homoharringtonine: an effective new natural product in cancer chemotherapy. Bull. Cancer 82, 987-995, (1995); Tujebajeva, R.M, et al., Selective inhibition of the polypeptide chain elongation in eukaryotic cells. Biochim. Biophys. Acta 1129, 177-182, (1992); Merck 14,10435 |
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MSDS: | ||
Description: |
Homoharringtonine is a cytotoxic alkaloid from the evergreen tree, Cephalotaxus hainanensis. Binds to the 80S ribosome in eukaryotic cells and inhibits protein synthesis by interfering with chain elongation. Blocks progression of leukemic cells from G1 phase into S phase and from G2 phase into M phase. |