Product: Lathosterol-2,2,4,4-d4
Catalog Number: D33670
Unlabeled CAS Number: 80-99-9
Pricing:
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Formula: C27H42D4O
Enrichment: 99 atom % D
Molecular Weight: 390.68
Structure: Lathosterol-2,2,4,4-d<sub>4</sub>
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Category: Labeled Steroids & Hormones
Literature References:

Kempen, H.J., Glatz, J.F., Leuven, J.A.G., van de Voort, H.A., Katan, M.B., Serum lathosterol concentration is an indicator of whole-body cholesterol synthesis in humans. The Journal of Lipid Research, 1988, Sep., 29:1149-1155.; Krakowiak, P.A., et al., Lathosterolosis: an inborn error of human and murine cholesterol synthesis due to lathosterol 5-desaturase deficiency. Hum. Mol. Genet., 2003, 12(13):1631-1641.

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Applications: The labeled direct precursor to cholesterol. By measuring the levels of lathosterol in a patients blood, the amount of cholesterol produced can be measured. Significantly elevated levels of lathosterol can identify patients with increased risk of premature coronary heart disease.