|Formula:||C14H17N3O2S • 2HCl|
|Category:||Protein Kinase Inhibitors and Activators|
|Stability:||Stable under recommended storage conditions.|
Keep container tightly closed in a dry and well-ventilated place
Non-hazardous for transport
Shirotani, et al., A new type of vasodilator HA 1077 an isoquinoline derivative inhibits proliferation of bovine vascular smooth muscle cells in culture. J. Pharmacol. Exp. Ther. 259, 738, (1991); Seto, et al., Effects of HA 1077 a protein kinase inhibitor on myosin phosphorylation and tension in smooth muscle. Eur. J. Pharmacol. 195, 267, (1991); Asano, et al., Vasodilator actions of HA 1077 in vitro and in vivo putatively mediated by the inhibition of protein kinase. Br. J. Pharmacol. 98, 1091, (1989); Merck 14,3942
Novel vasodilator agent which inhibits vascular smooth muscle contraction by acting as an intracellular Ca2+ antagonist.