Product: 1-(5-Isoquinolinesulfonyl)-1H-hexahydro-1,4-diazepine DiHCl
Catalog Number: 11238
CAS Number: 203911-27-7
Synonyms: HA1077 Dihydrochloride;
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Formula: C14H17N3O2S • 2HCl
Molecular Weight: 364.29
Structure: 1-(5-Isoquinolinesulfonyl)-1H-hexahydro-1,4-diazepine DiHCl
Appearance: Off-White Solid
Category: Protein Kinase Inhibitors and Activators
Stability: Stable under recommended storage conditions.

Keep container tightly closed in a dry and well-ventilated place


Non-hazardous for transport

Literature References:

Shirotani, et al., A new type of vasodilator HA 1077 an isoquinoline derivative inhibits proliferation of bovine vascular smooth muscle cells in culture. J. Pharmacol. Exp. Ther. 259, 738, (1991); Seto, et al., Effects of HA 1077 a protein kinase inhibitor on myosin phosphorylation and tension in smooth muscle. Eur. J. Pharmacol. 195, 267, (1991); Asano, et al., Vasodilator actions of HA 1077 in vitro and in vivo putatively mediated by the inhibition of protein kinase. Br. J. Pharmacol. 98, 1091, (1989); Merck 14,3942


Novel vasodilator agent which inhibits vascular smooth muscle contraction by acting as an intracellular Ca2+ antagonist.