Product: TRAM-34
Catalog Number: 13880
CAS Number: 289905-88-0
Synonyms: 1-[(2-Chlorophenyl)diphenylmethyl]-1H-pyrazole
Pricing:
25 mg =  $860   (In Stock) Add to Cart
50 mg =  $1,100   (In Stock) Add to Cart
Formula: C22H17ClN2
Chemical Purity: 98%
Molecular Weight: 344.84
Structure: TRAM-34
Appearance: Off-White Solid
Category: Heterocyclic Compounds
Stability: Stable under recommended storage conditions.
Storage:

Store as supplied, at room temperature for up to 1 year. Store solutions at -20° C for up to 3 months
Transportation:

Non-hazardous for transport.
Literature References:

Wulff, H., et al. 2000. Proc. Natl. Acad. Sci. U.S.A. 97: 8151-8156. PMID: 10884437; Chandy, K.G., et al. 2004. Trends Pharmacol. Sci. 25: 280-289. PMID: 15120495; Panyi, G., et al. 2006. Curr. Pharm. Des. 12: 2199-2220. PMID: 16787250; Wang, Z.H., et al. 2007. Oncogene. 26: 5107-5114. PMID: 17310992
MSDS:
Applications:

TRAM-34 has been shown to be an inhibitor of cloned and native IK1 channels in human T lymphocytes. These K+ channels have been implicated in over-proliferation of cells. Inhibition of IK1 channels has been demonstrated to modulate cell proliferation depending on the concentration of TRAM-34. Mechanistic studies have shown that TRAM-34 may cause a halt in cell growth at the G0/G1 phase