Product: Annonacin
Catalog Number: 17345
CAS Number: 111035-65-5
1 mg =  $990   Add to Cart
5 mg =  $1,650   Add to Cart
Molecular Weight: 596.88
Structure: Annonacin
Category: Anti-cancer compounds
Literature References:

Lannuzel, A.; Michel, P. P.; Höglinger, G. U.; Champy, P.; Jousset, A.; Medja, F.; Lombès, A.; Darios, F. et al., The Mitochondrial Complex I Inhibitor Annonacin is Toxic to Mesencephalic Dopaminergic Neurons by Impairment of Energy Metabolism. Neuroscience, 2003, 121 (2): 287–296.; Champy, P.; Höglinger, G. U.; Féger, J.; Gleye, C.; Hocquemiller, R.; Laurens, A.; Guérineau, V.; Laprévote, O. et al., Annonacin, a Lipophilic Inhibitor of Mitochondrial Complex I, induces Nigral and Striatal Neurodegeneration in Rats: Possible Relevance for Atypical Parkinsonism in Guadeloupe. Journal of Neurochemistry, 2003, 88 (1): 63–69.; McLaughlin, J. L.., Paw Paw and Cancer: Annonaceous Acetogenins from Discovery to Commercial Products. Journal of Natural Products, 2008, 71(7): 1311–1321.

Applications: An acetogenin. Blocks mitochondrial complex I, which is responsible for the conversion of NADH to NAD+ and the build-up of the proton gradient. Disables a cell's ability to genertate ATP leading to cell death.