Product: Cladribine
Catalog Number: 17421
CAS Number: 4291-63-8
Synonyms: 2-Chloro-2’-deoxyadenosine;
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Formula: C10H12ClN5O3
Chemical Purity: 97%
Molecular Weight: 285.69
Structure: Cladribine
Appearance: Solid
Category: Anti-cancer compounds
Stability: Stable under recommended storage conditions

Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: 2-8°C.


Non-hazardous for transport

Literature References:

Bryson, H.M. and Sorkin, E.M. Drugs 46, 872, (1993); Carson, D.A., et al. Proc. Natl. Acad. Sci. U. S. A. 81, 2232, (1984); Merck 14,2337


Cladribiane, like fludarabine, is a prodrug that is must be phosphorylated intracellularly to the monophosphate by the nuclear/cytosol enzyme deoxycytidine kinase (dCK) and possibly by the mitochondrial enzyme deoxyguanosine kinase (dGK). Clinically used for treatment of hairy cell leukemia, chronic lymphocytic leukemia and other indolent leukemias