Inquire About a Product| Product: | Cladribine | ||||
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| Catalog Number: | 17421 | ||||
| CAS Number: | 4291-63-8 | ||||
| Synonyms: |
2-Chloro-2’-deoxyadenosine; CdA |
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| Pricing: |
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| Formula: | C10H12ClN5O3 | ||||
| Chemical Purity: | 97% | ||||
| Molecular Weight: | 285.69 | ||||
| Structure: |
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| Appearance: | Solid | ||||
| Category: | Anti-cancer compounds | ||||
| Stability: | Stable under recommended storage conditions | ||||
| Storage: |
Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: 2-8°C. |
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| Transportation: |
Non-hazardous for transport |
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| Literature References: |
Bryson, H.M. and Sorkin, E.M. Drugs 46, 872, (1993); Carson, D.A., et al. Proc. Natl. Acad. Sci. U. S. A. 81, 2232, (1984); Merck 14,2337 |
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| MSDS: | |||||
| Description: |
Cladribiane, like fludarabine, is a prodrug that is must be phosphorylated intracellularly to the monophosphate by the nuclear/cytosol enzyme deoxycytidine kinase (dCK) and possibly by the mitochondrial enzyme deoxyguanosine kinase (dGK). Clinically used for treatment of hairy cell leukemia, chronic lymphocytic leukemia and other indolent leukemias |