Product: 2-Fluoroadenine-9-β-D-arabinofuranoside
Catalog Number: 32261
CAS Number: 21679-14-1
Synonyms: 9-β-Arabinofuranosyl-2-fluoroadenine;
Fludarabine des-phosphate
5 mg =  $990   (In Stock) Add to Cart
10 mg =  $1,500   (In Stock) Add to Cart
Formula: C10H12FN5O4
Molecular Weight: 285.23
Structure: 2-Fluoroadenine-9-β-D-arabinofuranoside
Appearance: White powder
Category: Nucleotides and Nucleosides Alphabetic Listing
Stability: Stable under recommended storage conditions

Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: 2 - 8°C


Non-hazardous for transport

Literature References:

Wyczechowska, D., and Fabianowska-Majewska, K., The effects of cladribine and fludarabine on DNA methylation in K562 cells Biochem. Pharmacol. 65, 219-225, (2003); Huang, P., and Plunkett, W. Mol. Pharmacol. 39, 449, (1991); Keating, M.J., et al. Blood 74, 19, (1989); Merck 14,4126


Fludarabine (the 5′-phosphate) is a prodrug that is converted to F-ara-A, which enters cells and accumulates primarily as the 5′-triphosphate. F-ara-A interferes with DNA synthesis and repair and induces apoptosis of cancer cells. F-ara-A also strongly inhibits DNA methylation, particularly methylation of cytosine in CpG dinucleotide sequences