Product: Doxorubicin HCl
Catalog Number: 9812
CAS Number: 25316-40-9
Synonyms: (8S,10S)-10-[(3-Amino-2,3,6-trideoxy-α-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-5,12-naphthacenedione;
10 mg =  $190   (In Stock) Add to Cart
50 mg =  $690   (In Stock) Add to Cart
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Formula: C27H31ClNO11
Chemical Purity: 99%
Molecular Weight: 579.98
Structure: Doxorubicin HCl
Appearance: Orange to dark orange-red powder
Category: Antibiotics
Stability: Stable under recommended storage conditions.

Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature 2-8 °C. Moisture sensitive. Light sensitive


Non-hazardous for transport

Literature References:

C.N. Ellis et al. Biochem. J. 245, 309, (1987); R.J. White et al. Drugs Pharm. Sci. 22, 569, (1984); A. Vigevani, M.J. Williamson Anal. Profiles Drug Subst. 9, 245, (1980); Gong, Y., et al. J. Biol. Chem. 278, 50234-50239, (2003); Rajagopal, A., and Simon, S.M. Mol. Biol. Cell 14, 3389-3399, (2003); Venkatachalam, K., et al., Neutralization Of Interleukin-18 Ameliorates Ischemia/reperfusion-induced Myocardial Injury. J. Thorac. Cardiovasc. Surg. 284, 7853-65, (2009); Park, J.Y., et al., Doxorubicin Enhances CD4(+) T-cell Immune Responses By Inducing Expression Of CD40 Ligand And 4-1BB. Int. Immunopharmacol. 9, 1530-9, (2009); Simpson, N.E., et al., High Levels Of Hsp90 Cochaperone P23 Promote Tumor Progression And Poor Prognosis In Breast Cancer By Increasing Lymph Node Metastases And Drug Resistance. Cancer Res. 70, 8446-56, (2010); Benson, E.K., et al., Role Of Progerin-induced Telomere Dysfunction In HGPS Premature Cellular Senescence. J. Cell Biol. 123, 2605-12, (2010); Ahn, J., et al., Srg3, A Mouse Homolog Of BAF155, Is A Novel P53 Target And Acts As A Tumor Suppressor By Modulating P21(WAF1/CIP1) Expression. Oncogene 30, 445-56, (2011); Cheng, J., et al., Poly(ethylene Glycol)-conjugated Multi-walled Carbon Nanotubes As An Efficient Drug Carrier For Overcoming Multidrug Resistance. Toxicol. Appl. Pharmacol. 250, 184-93, (2011); Friesen, C., et al., Cytotoxic drugs and the CD95 pathway. Leukemia 13, 1854, (1999); Kraus-Berthier, L, et al., Histology and sensitivity to anticancer drugs of two human non-small cell lung carcinomas implanted in the pleural cavity of nude mice. Clin. Cancer Res. 6, 297-304, (2000); Sparano, J.A., Doxorubicin/taxane combinations: cardiac toxicity and pharmacokinetics. Semin. Oncol. 26, 14-19, (1999)

Applications: Used in cancer chemotherapy as an anthracycline antitumor antibiotic. Intercalates DNA. Used as a treatment in a wide range of cancer such as, hematological malignancies, many types of carcinomas, and soft tissue sarcomas