|Synonyms:||24-Hydroxy Cholesterol-d6, 24-Hydroxy Cholesterol deuterated|
Bjorkhem, I., Lutjohann, D., Breuer, O., Sakinis, A., Wennmalm, A., Importance of a Novel Oxidative Mechanism for Elimination of Brain Cholesterol Turnover of Cholesterol and 24(S)-Hydroxycholesterol in Rat Brain as Measured with 18O2Techniques in vivo and in vitro. The Journal of Biological Chemistry, 1997, Nov., 272:30178-30184.; Kolsch, H., Lutjohann, D., Tulke, A., Bjorkhem, A., Rao, M.L., The neurotoxic effect of 24-hydroxycholesterol on SH-SY5Y human neuroblastoma cells. Brain Research, 1999, Feb., 818(1):171-175.
|Applications:||A labeled derivative of cholesterol. Synthesized exclusively in the brain. Possesses the ability to cross the blood-brain barrier. Maintains brain cholesterol homeostasis. Precursor to bile acids. Correlation between increased levels of the compound and the occurrence of active demyelinating diseases such as Alzheimer's disease.|