A chiral derivatizing agent (CDA) also known as a chiral resolving reagent, is a chiral auxiliary which can convert a mixture of enantiomers into diastereomers in order to analyse the quantities of each enantiomer present within the mix. In NMR spectroscopy these compounds are called chiral shift reagents. Since NMR spectroscopy has been available to chemists, there have been numerous studies on the applications of this technique. One of these noted the difference in the chemical shift (i.e. the distance between the peaks) of two diastereomers.[1] Conversely, two compounds that are enantiomers have the same NMR spectral properties. It was reasoned that if a mix of enantiomers could be converted into a mix of diastereomers by bonding them to another chemical that was itself chiral, it would be possible to distinguish this new mixture using NMR, and therefore learn about the original enantiomeric mixture. The first popular example of this technique was published in 1969 by Harry S. Mosher. The chiral agent is a single enantiomer of MTPA (á-methoxy-á-(trifluoromethyl)phenylacetic acid), also known as Mosher’s acid.[2] The corresponding acid chloride is also known as Mosher’s acid chloride, and the resultant diastereomeric esters are known as Mosher’s esters. Another system is Pirkle’s Alcohol developed in 1977